ABSTRACT
Purpose: Larynx cancer is the most common head-and-neck cancer in Turkey. Vocal cords are involved nearly 70%–80% of laryngeal carcinomas. We aim to present our 10 years' experience and failure patterns of the patients with T1 and T2 glottic laryngeal carcinoma by same manner, technique, doses, and physician in conformal radiotherapy (RT) era. Methods: Between January 2005 and December 2015, a total of 143 patients treated with definitive RT for early-stage glottis laryngeal cancer were selected. The total dose was 65.25 Gy in 29 fractions. Results: The median follow-up time was 64 (range: 12–150) months. All of the patients had a complete clinical response to the treatment. A 5-year local control (LC) rates were 84.5%, 91.8%, 74%, and 56% for overall, T1a, T1b, and T2, respectively. Ultimate LC rates (after salvage treatment) for 5 years were 90%, 95%, 92%, and 75% for overall, T1a, T1b, and T2, respectively. Regional neck control for the whole group was 92% for 5 years. After the initial RT, a total of 22 (15.4%) patients had disease recurrence at any site of the neck or larynx. Median time to disease recurrence was 59.5 months (range: 5–150). Conclusion: This study represents a large and long-term analysis of early-stage glottic carcinoma treated by same manner, technique, doses, and physician in conformal RT era. Definitive RT provides a high LC rate, tolerable toxicity, and favorable voice quality. Extension beyond the vocal cords and T2 stage are the most important unfavorable prognostic factors regarding LC
ABSTRACT
Background/Aim: Gastric cancer causes the second highest number of cancer related deaths. The purpose of this study is to evaluate the survival of patients who are T3, T4, lymph node positive postoperatively and have undergone adjuvant chemoradiotherapy (CRT). We also examined the toxicities of CRT. Materials and Methods: Included in this retrospective study were one hundred six, stage IIA, IIB, IIIA, IIIB and IIIC gastric cancer patients undergoing adjuvant chemoradiotherapy after four weeks of surgery presenting at our hospital between 2009 and 2013. Statistical analysis was done with the SPSS (version 19) programme and survival analysis was done by using the Kaplan-Meier method. Results: The median follow-up of patients was 25 months (range; 7-38). There were local recurrences in 25.9% (n=22) of patients and liver metastasis in 20% (n=17), lung metastasis in 16.5% (n=14) and peritoneal metastasis in 5.9% (n=5). There were no recurrences in 31.8% (n=27) of patients. The median disease free survival (DFS) of the patients was 11 months (8.4- 13.5) and overall surival (OS) was 29 months (24.3-33.6). Conclusion: Survival rates were found to be lower than expected, this could be due to ongoing dietary habits and the low socioeconomic status of the patients. Toxicities were manageable.